Isicelo sokujova isihlungu senyoka i-hemagglutinin
I-enzyme yokujikisa igazi yekilasi lenyoka enobuthi inobuthi obuphansi, isebenza ngokushesha (imizuzu emi-5 ~ 30 ngemuva kokwelashwa ingaveza umphumela we-hemostatic), isebenze isikhathi eside (ngemuva komphumela wokusebenza isimeme amahora angama-48 ~ 72) njll, futhi isetshenziswa kabanzi ezidingweni zomtholampilo. ukunciphisa ukopha noma izimo ukopha (njengokuhlinzwa, imithi yangaphakathi, obstetrics kanye gynecology, ophthalmology, otolaryngology, umlomo cavity ukopha kanye nezifo hemorrhagic), Ingase futhi isetshenziselwe ukuvimbela ukopha (isibonelo, imithi ngaphambi kokuhlinzwa ingagwema noma ukunciphisa ukopha endaweni yokuhlinzwa nangemuva kokuhlinzwa).Ngokwemibiko yezincwadi, izinga elisebenzayo lobuthi benyoka i-hemagglutinin ekuhlinzweni kwe-hemostasis nokopha kwamathumbu lingcono kakhulu kunele-phenolsulfonamides, i-sodium caroxesulfonate, i-vitamin K nezinye izidakamizwa ze-hemostatic.
Imijovo ye-hemagglutinin ye-snake poison hemagglutinin ngaphambilini eyayithengiswa emakethe ihlanganisa umjovo we-snake venom hemagglutinin (igama lokuhweba: Sulejuan), umjovo we-snake venom hemagglutinin (igama lokuhweba: Bangting), umjovo we-agkistrodon halys hemagglutinin (igama lokuhweba: Nokho, akukho ukuhlola okuhlelekile okubonisa ukuthi umehluko omkhulu ekusebenzeni kahle kwe-hemostatic kanye nesigameko sokusabela okubi phakathi kwezinyoka ezintathu.
I-enzyme yesigaba se-snake venom ye-blood clotting enzyme iyilungiselelo lebhayoloji, elisuka esakhiweni samakhemikhali, liyingxenye yeprotheyini ye-heterologous, namaseli e-mast ku-vivo noma i-basophilic cell surface molecules, uchungechunge lokusabela kuseli, izinto ezisebenzayo ze-vascular, ezifana nokukhululwa kwe-histamine, izinto zokusabela kancane, uhlobo Ⅰ imiphumela yokungezwani komzimba emzimbeni, ingase futhi ihlotshaniswe ne-enzyme iqukethe ukungcola.Ngesikhathi esifanayo, kokubili ukuhlukumezeka kokuhlinzwa kanye nobuhlungu be-postoperative kungaholela ekuphenduleni kwesigaba esibucayi (APR), njengokukhuphuka kokushisa komzimba, ukwanda kweglucose yegazi, ukwanda kwe-catabolism, ibhalansi ye-nitrogen engalungile kanye nokukhula kwe-plasma acute phase protein (APP) ukugxila.Ngalesi sikhathi ukunikeza amaprotheni allogenic, umzimba ithambekele yokungezwani komzimba, noma ngisho iguliswa kakhulu.UZhao Shanshan et al.ihlaziye izincwadi ezimayelana nemibiko yecala lokusabela okungekuhle komjovo we-snake venom hemagglutinase, futhi yathola ukuthi izehlakalo ezingama-57 kwezingu-69 zokusabela okubi zenzeka phakathi nehora elingu-1 ngemva komjovo, futhi ezingu-35 zazo zenzeka phakathi nemizuzu engu-1 ~ 5 ngemva komjovo.Ukusabela okuguquguqukayo kwe-acute okusheshayo, uma kutholakala ngesikhathi noma ukuphathwa okungalungile, ukuthuthukiswa okusheshayo kwesifo futhi kuyingozi, kuzodala imiphumela emibi ezigulini.
Ngakho-ke, izinkomba kufanele zilawulwe ngokuqinile ekusetshenzisweni komtholampilo, futhi umlando wezokwelapha wesiguli, umlando wemithi, umlando wokungezwani komzimba kanye nomlando womndeni kufanele kubuzwe ngokucophelela ngaphambi kokusetshenziswa kokuqala.Lungiselela imithi nama-athikili adingekayo ukuze uthole ukwelashwa okuphuthumayo ngaphambi kokusetshenziswa.Ijubane lomjovo kufanele lihambe kancane, futhi izimpawu ezibalulekile zeziguli nezinye izinguquko kufanele zibhekwe eduze ekuqaleni komuthi.Ngemva kokubheka ngokucophelela imizuzu embalwa, iziguli zingahamba ukuze ziqinisekise ukuthi akukho ukusabela okubi.