Ukusetshenziswa Kwesihlungu Senyoka Ukumisa Ukopha Kanye Ne-Anticoagulation Isithombe Esifakiwe

Ukusetshenziswa Kwesihlungu Senyoka Ukumisa Ukopha Nokunqanda I-Anticoagulation

Incazelo emfushane:

Ngo-1981, i-defibrase ekhishwe futhi yathuthukiswa yi-Kunming Institute of Zoology, e-Yunnan, e-China, kusukela ebuhlungwini benyoka ye-pentameter yaseShayina yadlula ukuhlolwa kobuchwepheshe futhi yasetshenziswa ekwelapheni amacala angu-333 we-vascular thrombosis, kuhlanganise namacala angu-242 we-cerebral thrombosis, izinga elisebenzayo lama-86.4%.I-agkistrodon agkistrodon acidase, ethuthukiswe yi-China Medical University kanye ne-Shenyang Pharmaceutical College, isetshenziswe ekwelapheni imithambo yemithambo ngemiphumela yomtholampilo eyanelisayo.Ilabhorethri ye-Snake Venom Laboratory yaseChina Medical University yathuthukisa i-enzyme ye-antacid yenyoka, enganciphisa i-lipids yegazi, ivule imithambo yegazi, inciphise okuqukethwe kwe-thrombin egazini, ikhulise i-prostacyclin, futhi ikhulule imisipha ebushelelezi yemithambo yegazi.Kuyilungiselelo elifanele le-anticoagulant thrombolytic.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

1. "i-defibrase" ekhishwe futhi yathuthukiswa ebuhlungwini be-pentapodes yaseShayina yagunyazwa yi-Kunming Institute of Zoology, e-Yunnan, e-China ngo-1981. Yasetshenziselwa ukwelapha amacala angu-333 we-vascular thrombosis, kuhlanganise namacala angu-242 we-cerebral thrombosis, izinga elisebenzayo lama-86.4%.
2. I-Agkistrodon agkistrodon acidase, eyakhiwe ngokuhlanganyela yi-China Medical University kanye ne-Shenyang Pharmaceutical College, izuze imiphumela eyanelisayo yomtholampilo ekwelapheni i-vascular occlusives.
3. Ilabhorethri ye-Snake Venom Laboratory yaseChina Medical University yathuthukisa i-enzyme ye-antacid yenyoka, enganciphisa i-lipids yegazi, ivule imithambo yegazi, inciphise okuqukethwe kwe-thrombin egazini, ikhulise i-prostacyclin, futhi ikhulule imisipha ebushelelezi yemithambo yegazi.Kuyilungiselelo elifanele le-anticoagulant thrombolytic.
4. Ubuthi benyoka obunezinyathelo ezinhlanu
I-Antivenomous snake serum iwuhlobo lomuthi, okuwumkhiqizo webhayoloji womjovo owenziwe nge-plasma yehhashi egonywe ngobuthi be-agkistrodon (agkistrodon), egaywe nge-enzyme bese ikhishwa usawoti.Iqukethe i-2000U antivenomous snake serum.Lolu hlobo lwalungiselelwa ukugaya kwe-enzyme kanye nokufakwa kukasawoti ku-plasma yamahhashi egonywe ngobuthi obuvela ku-A. agkistrodon.

5. Ukubambisana kocwaningo lwemboni-yenyuvesi
I-Mashan Longshe Snake Industry Co., Ltd. ibambisene ne-snake Venom Institute yase-Guangxi Medical University ukunikeza ubuthi benyoka obuseqophelweni eliphezulu isikhathi eside, obusetshenziselwa ukutadisha i-biochemistry, i-molecular biology kanye ne-pharmacology ye-snake poison protein, kanye uye wengamela amaphrojekthi angaphezu kwe-10 njengeNational Natural Science Foundation kanye namaphrojekthi oMnyango Wesayensi Nobuchwepheshe waseGuangxi.Iwine umklomelo wesibili we-Guangxi Science and Technology Progress Award kanye nomklomelo wesithathu we-Guangxi Science and Technology Progress Award.

6. I-Snake hemagglutinin iyi-ejenti ye-hemostatic enomphumela ofana ne-thrombin kinase, engaguqulwa ibe i-fibrin nge-hydrolyzing fibrinogen, ngaleyo ndlela ithuthukise ukusebenza komzimba;Lo mkhiqizo futhi unomsebenzi wokuthuthukisa ukuhlangana kweplatelet, okungabangela ukuhlangana okungenakuhlehliswa kwamaplatelet, ngaleyo ndlela kuthuthukise umsebenzi wokuhlangana, kodwa akukhuthazi ukuhlangana kweplatelet emithanjeni yegazi engaguquki.
I-Hemocoagulation ye-agkistrodon agkistrodon njengosizo lwe-hemostasis yesilonda esingaphezulu ekuhlinzeni.