Ukusetshenziswa Seven Antithrombotic Agents
Kunezinhlobo ezimbili zamaprotheni anomphumela we-antithrombotic ebuhlungwini benyoka, eyodwa iyakwazi ukwenza I-enzyme exhunywe ne-fibrinolytic enzyme ibizwa ngokuthi i-fibrinolytic enzyme (i-plasmine, FLE). i-hydrolysis yezinye izici ze-coagulation Kanye nolwelwesi lweplatelet, olunomphumela osobala we-antithrombotic.Okunye ngokucindezela ukulungiswa kweProthrombin kucushiwe ukuze kubambezeleke inqubo yokuhlangana, futhi ayinawo umsebenzi we-enzyme.
Lolu hlobo lwe-enzyme lwaqala ukukhiqizwa ngu-Atoda et al Futhi uxoxe ngendlela ye-anticoagulation ye-anticoagulant protein, Kuyaqinisekiswa ukuthi umphumela we-coagulation factor IX noma i-coagulation factor X ku-ion ye-calcium Ukwenza i-1: i-1 eyinkimbinkimbi yokwandisa isikhathi sokuhlanganisa;Kamuva, uLu et al.kusuka ku-Agkistrodon acutus eningizimu ye-Anhui I-anticoagulant factor ACFI yahlukaniswa nobuhlungu benyoka.U-Liu Qing Liang et al.ithole ukuthi i-ACFI iqukethe i-calcium ion, Kwaqinisekiswa futhi ukuthi umsebenzi wayo we-anticoagulant kanye nesakhiwo sendawo kwakuhlobene ne-calcium ions. Kamuva, u-Xu Xiaolong nabanye bahlukanisa ubuthi be-Agkistrodon acutus ne-Agkistrodon acutus ngendlela yokuhlukanisa ethuthukisiwe Esinye isici se-anticoagulant ACFI I The ucwaningo lokusetshenziswa komshini luthole ukuthi iyafana ne-AC FI futhi ingeyesigaba sesibili.UZhai Ning et al.yahlukanisa isici se-ne anticoagulant ebuhlungwini be-Agkistrodon acutus, kanye nezakhiwo zayo ezingokomzimba namakhemikhali zacwaningwa, futhi kwatholakala ukuthi yayingenawo umsebenzi we-fibrinolytic futhi ayinawo umsebenzi we-phospholipase A 2 nomsebenzi wokopha.U-Qian Xiaojiang nabanye bahlukanisa ubuthi be-Agkistrodon acutus ne-Hunan Ingxenye esebenzayo ye-fibrinolytic yahlukaniswa futhi yaqinisekiswa ukuhlolwa kwe-thrombolytic in vitro Inomphumela osobala we-thrombolytic.U-Lei Danqing wahlukaniswa ngezindlela ezintathu ze-chromatography Futhi umsebenzi we-plasmin uthuthukiswa kakhulu.Ngenxa yokuthi ingxenye ye-plasmin iqukethe Ingxenye yokopha kunzima ukuhlukaniswa, futhi inani layo lesicelo somtholampilo alibonakali.U-Li Zhaoyan et al Ngemizamo yokuthola i-enzyme ye-fibrinolytic ngaphandle kwezingxenye zokopha Ukwesekwa kwezobuchwepheshe kunikezwa.U-Zhou Xianli [18] ufakazele ngokuhlolwa ukuthi i-Thrombin njenge-enzyme ne-plasmin evela ku-Agkistrodon halys venom inomphumela osobala we-thrombolytic, kodwa Umphumela oqondile we-plasmin unamandla kunalowo we-thrombin njenge-enzyme, Ngakho-ke, i-thrombin njenge-enzyme iyi-ejenti ye-thrombolytic, kwenza ukuvuselelwa kwemithambo yegazi kancane kancane, Thuthukisa ukubekezelelana kwemithambo yegazi endaweni ye-ischemic, futhi usinde ekuqhekekeni kwemithambo okubangelwa ukugcwala kwegazi I-cleavage inomphumela omuhle esigabeni sokuqala se-thrombosis, futhi zombili zisetshenziswa ndawonye, Kunganciphisa Imithamo exhunywe ne-fibrinolytic enzyme ibizwa nge-fibrinolytic enzyme (plasmine, FLE) izinhlobo ezimbili zamaphrotheni ezinomphumela we-antithrombotic ebuhlungwini benyoka. i-fibrin ne-fibrinogen eyehlisa isithunzi, Akukho ukusebenza kwe-plasminogen emzimbeni womuntu, akukho hydrolysis kwezinye izici coagulation Kanye nolwelwesi lweplatelet, olunomphumela osobala we-antithrombotic.Okunye ngokucindezela ukulungiswa kweProthrombin kucushiwe ukuze kubambezeleke inqubo yokuhlangana, futhi ayinawo umsebenzi we-enzyme.
Lolu hlobo lwe-enzyme lwaqala ukukhiqizwa ngu-Atoda et al Futhi uxoxe ngendlela ye-anticoagulation ye-anticoagulant protein, Kuyaqinisekiswa ukuthi umphumela we-coagulation factor IX noma i-coagulation factor X ku-ion ye-calcium Ukwenza i-1: i-1 eyinkimbinkimbi yokwandisa isikhathi sokuhlanganisa;Kamuva, uLu et al.kusuka ku-Agkistrodon acutus eningizimu ye-Anhui I-anticoagulant factor ACFI yahlukaniswa nobuhlungu benyoka.U-Liu Qing Liang et al.ithole ukuthi i-ACF iqukethe i-calcium ion Kwabuye kwaqinisekiswa ukuthi umsebenzi wayo we-anticoagulant kanye nesakhiwo sendawo kwakuhlobene ne-calcium ions.Kamuva, u-Xu Xiaolong kanye nabanye bahlukanisa ubuthi be-Agkistrodon acutus ne-Agkistrodon acutus ngendlela yokuhlukanisa ethuthukisiwe Enye into elwa nokuvuvukala kwe-ACFI I Ucwaningo lokusetshenziswa komshini lwathola ukuthi lufana ne-AC FI futhi lungokwesigaba sesibili.UZhai Ning et al.yahlukanisa isici esisha se-anticoagulant ebuhlungwini be-Agkistrodon acutus, futhi izici zayo ezingokomzimba namakhemikhali zacwaningwa, futhi kwatholakala ukuthi yayingenawo umsebenzi we-fibrinolytic futhi ayinawo umsebenzi we-phospholipase A 2 kanye nomsebenzi wokopha.U-Qian Xiaojiang nabanye bahlukanisa ubuthi be-Agkistrodon acutus ne-Hunan Ingxenye esebenzayo ye-fibrinolytic yahlukaniswa futhi yaqinisekiswa ukuhlolwa kwe-thrombolytic in vitro Inomphumela osobala we-thrombolytic.U-Lei Danqing wahlukaniswa ngezindlela ezintathu ze-chromatography Futhi umsebenzi we-plasmin uthuthukiswa kakhulu.Ngenxa yokuthi ingxenye ye-plasmin iqukethe Ingxenye yokopha kunzima ukuhlukaniswa, futhi inani layo lesicelo somtholampilo alibonakali.U-Li Zhaoyan et al Ngemizamo yokuthola i-enzyme ye-fibrinolytic ngaphandle kwezingxenye zokopha Ukwesekwa kwezobuchwepheshe kunikezwa.U-Zhou Xianli [18] ufakazele ngokuhlolwa ukuthi i-Thrombin njenge-enzyme ne-plasmin evela ku-Agkistrodon halys venom inomphumela osobala we-thrombolytic, kodwa Umphumela oqondile we-plasmin unamandla kunalowo we-thrombin njenge-enzyme, Ngakho-ke, i-thrombin njenge-enzyme iyi-ejenti ye-thrombolytic, yenza ukuvuselelwa kwemithambo yegazi kancane kancane, Thuthukisa ukubekezelelana kwemithambo yegazi endaweni ye-ischemic, futhi usinde ekuqhekekeni kwemithambo okubangelwa ukugcwala kwegazi I-cleavage inomphumela omuhle esigabeni sokuqala se-thrombosis, futhi zombili zisetshenziswa ndawonye.
Inganciphisa umthamo futhi izuze imiphumela ye-anticoagulant ne-thrombolytic.
Isikhathi sokuthumela: Oct-19-2022