Ngenxa yokuthi imithi yaseShayina yendabuko ikholelwa ukuthi iyingxenye yesigaba "sempahla yenyama negazi", iyaziswa kakhulu.Umuthi wendabuko wamaShayina wezilwane ezinobuthi udlala indima ebalulekile ocwaningweni nasekusetshenzisweni kwemithi yesintu.Kodwa-ke, okwamanje, luncane ucwaningo mayelana nezingxenye ezithile ezisebenzayo kanye nendlela yokusebenza yezilwane ezinobuthi zomuthi wendabuko waseShayina.Ibhodlela eliyinhloko ukuthi izingxenye zalo ziyinkimbinkimbi, kunzima ukuhlukanisa nokuhlanza, futhi kunzima ukukhomba isakhiwo sayo.U-Lai Ren, u-Xioning Yuliang, u-Zhang Yun, u-Xiao Changhua, u-Wang Wanyu kanye namanye amalungu ethimba labacwaningi le-Kunming Institute of Zoology, i-Chinese Academy of Sciences sekuyisikhathi eside befunda isisekelo sezinto ezibonakalayo kanye nendlela yokusebenza komuthi wendabuko waseShayina wezilwane ezinobuthi, yasungula umtapo wolwazi osebenzayo wamangqamuzana asebenzayo, yathuthukisa izidakamizwa eziningi ezintsha, futhi kancane kancane yasungula "uhlelo lobuchwepheshe bezimayini oluhlosiwe lwezingxenye ezisebenzayo zomuthi wendabuko waseShayina wezilwane ezinobuthi ngokusekelwe kumasu okusinda kwezinto eziphilayo".Izici zalolu hlelo lobuchwepheshe yilezi: 1) ukuqamba okusha kwethiyori: ukuthatha isu lokusinda kwezilwane ezinobuthi njengesiqondiso sethiyori sokuhlola izingxenye zokusebenza;I-2) Ukuqamba okusha kwezobuchwepheshe: ama-proteomics ahlanganiswe ne-pharmacology asetshenziselwa ukulandelela ukuhlukaniswa nokuhlanzwa kwezingxenye zokusebenza;3) Ukuqamba okusha okuhlanganisiwe: dala uhlelo lobuchwepheshe lwezimayini oluqondiwe lwezingxenye ezisebenzayo zezilwane ezinobuthi kanye nemithi yendabuko yamaShayina esekelwe kumasu okusinda kwebhayoloji, ukuhlonza isisekelo esibonakalayo samasu azo okusinda, futhi uveze isisekelo sezinto ezibonakalayo nendlela yokusebenza yaleyo mithi yendabuko yamaShayina.Ngalolu hlelo lobuchwepheshe, bahlonze ukukhululeka kobuhlungu, ukopha, i-antithrombotic, i-hypotensive, i-anti-cancer, i-anti-bacterial, i-anti-oxidation, i-anti rheumatic arthritis Ukulawulwa kwamasosha omzimba kanye namanye ama-molecule asebenzayo aveza isisekelo salezi zinto zokwelapha ukuze zisebenzise ukusebenza kwazo. , futhi afakazele ngokuqondile ukusebenza kwalolu hlobo lwemithi yendabuko yamaShayina ezingeni lamangqamuzana;Ngesikhathi esifanayo, iphinde yahlonza ezinye izinto ezibangela ukungezwani komzimba, ukopha kanye neminye imiphumela engemihle ehlobene, enikeza isiqondiso sokusetshenziswa okuphephile kwalezi zinto zokwelapha.Lolu chungechunge lomsebenzi lwenze isisekelo esiqinile sokwenziwa kwesimanjemanje kwemithi yendabuko yamaShayina kanye nocwaningo nokuthuthukiswa kwemithi emisha yalolu hlobo lwezidakamizwa.Ithole amalungelo obunikazi okusungulwa okungu-30 kanye nobunikazi bemodeli yokusetshenziswa engu-1, ekhiqize inani elihle lesayensi, lezenhlalo nezomnotho, eliboniswa ikakhulukazi: 1) ekudaluleni izithako ezithile ezisebenzayo zale mithi yendabuko yamaShayina ezingeni lamangqamuzana.Baye bahlonza ama-molecule angaphezu kuka-800 asebenzayo avela kulezi zinto zokwelapha (okuhlanganisa ama-peptide e-antimicrobial, i-bradykinin, i-tachykinin, i-antithrombotic peptides, i-protease inhibitors, ama-proteases, i-bombesin, i-antioxidant peptides, ama-immunosuppressants, i-phospholipase, i-melittin, i-neurodestoxic, i-peptides nokunye ukulungiswa kwesikhumba). futhi yahlaziya izinhlaka zazo, izinhloso zokwenza kanye nezindlela;2) Ukuhlonzwa kwamaqembu amangqamuzana asebenzayo kunikeza isisekelo sesayensi sokwakhiwa, ukucubungula kanye nokusetshenziswa kwalawa mazinga emithini yendabuko yamaShayina;3) Ukuhlonza izinto ezinobuthi obungaseceleni njengezinto ezingezwani nalutho kule mithi ye-herbal yaseShayina kunikeza indlela yokuhlukanisa nokususa ubuthi nemiphumela engemihle kule mithi ye-herbal yaseShayina, futhi inikeza imibono yokuxilongwa nokuvimbela ubuthi obunjalo be-herbal Chinese;4) Amanye ama-molecule asebenzayo atholakala kubuthi bezilwane athuthukiswe aba izidakamizwa zomtholampilo noma asathuthukiswa, okuhlanganisa i-cobra polypeptide neurotoxin polypeptide, i-agkistrodon acutus venom thrombin, i-vespid polypeptide, i-gadfly anti laren, owazalwa ngo-1972, umcwaningi kanye nomqondisi wodokotela we-Kunming Institute of I-Zoology, i-Chinese Academy of Sciences, eyawina i-National Science Fund for Distinguished Young Scholars, futhi yethula amathalenta “Ohlelweni Lwamathalenta Ayikhulu” lwe-Chinese Academy of Sciences ngo-2004. Kusukela ngoJanuwari 2014, amaphepha e-SCI ayi-125 ashicilelwe njengawokuqala noma umbhali ohambelanayo, njengeProc Natl Acad Sci, Mol Cell Proteomics, Hypertension, njll;Umenywe ukusebenza njengesekela lomhleli we-J Venom Res;Ifake isicelo samalungelo obunikazi okusungulwa angaphezu kuka-70.Senze izinhlelo ezibalulekile zeNational Natural Science Foundation yaseChina, iNational Science Fund for Distinguished Young Scholars, Uhlelo lwama-973 loMnyango Wezesayensi Nobuchwepheshe, uhlelo olukhulu olusha lokutholwa kwezidakamizwa, kanye nezinhlelo eziqondisayo zeChinese Academy. WezeSayensi.Iwine ngokulandelana i-National Technological Invention Award (2013, ikleliswe kuqala), i-China Youth Science and Technology Award (2011), i-Tan Jiazhen Life Science Award (2010) nezinye izindondo.I-Thrombotic polypeptide, i-centipede polypeptide, njll;5) Senze izindlela zokwelapha ubuthi benyoka kanye nobuthi bezinyosi, sinikeza izindlela zobuchwepheshe ezisebenzayo zokwelapha iziguli ezinobuthi benyoka kanye nobuthi bezinyosi.I-Kunming Institute of Zoology, i-Chinese Academy of Sciences izuze imiphumela yocwaningo ephawulekayo emikhakheni efanele: eminyakeni yamuva nje, ishicilele amaphepha e-SCI angaphezu kuka-200, futhi yawina imiklomelo yokuqala yezifundazwe neyongqongqoshe emi-4 kanye nemiklomelo yesi-6 yesibili.Ngo-2013, i-Kunming Institute of Zoology, i-Chinese Academy of Sciences yawina umklomelo wesibili we-National Technological Invention Award yephrojekthi "I-Directional Mining Technology System Yezingxenye Ezisebenzayo Zomuthi Owubuthi Wezilwane Zendabuko YamaShayina Ngokusekelwe Kusu Lokusinda Kwezinto Eziphilayo".
Isikhathi sokuthumela: Dec-09-2022