I-Institute of Snake Venom and Snakebite, eSouthern Anhui Medical College

I-Institute of Snake Venom and Snakebite, eSouthern Anhui Medical College

Isikhungo Sokucwaninga saseWuhu City, esifundazweni sase-Anhui

Ucwaningo ngobuthi benyoka nesilonda senyoka lwaseSouthern Anhui Medical College lwaqala phakathi nawo-1970, futhi wayeyilungu le-Anhui Provincial Snake Wound Treatment Cooperation Group ngaleso sikhathi.Ingesinye sezikhungo zakuqala ukwenza ucwaningo oluyisisekelo nolusetshenziswayo ngobuthi benyoka eChina.

Igama lesiShayina

I-Institute of Snake Venom and Snakebite, eSouthern Anhui Medical College

indawo

Isifunda sase-Anhui

uhlobo

isikole sabagogothile

into

Ubuthi Benyoka Nenxeba Lenyoka

Izimpumelelo zocwaningo zeSikhungo

Isingeniso Sesikhungo

Ucwaningo ngobuthi benyoka nesilonda senyoka lwaseSouthern Anhui Medical College lwaqala phakathi nawo-1970, futhi wayeyilungu le-Anhui Provincial Snake Wound Treatment Cooperation Group ngaleso sikhathi.Ngo-1984, ngaphansi kobuholi bukaProfessor Wen Shangwu, umqondisi womnyango wokufundisa nokucwaninga wabafundi bokuqala ababegula, kwasungulwa iHhovisi Lokucwaninga Nge-Snake Poison and Snakebite, okungesinye sezikhungo zokuqala ukwenza ucwaningo oluyisisekelo nolusetshenziswayo. ngobuthi benyoka eChina.Ngo-2007, i-Snake Poison and Snakebite Research Office yaqanjwa kabusha ngokuthi i-Snake Poison Research Institute of Southern Anhui Medical College, kanti umqondisi wamanje nguSolwazi Zhang Genbao.Eminyakeni engu-30 edlule, impumelelo yocwaningo eyisisekelo nesetshenziswayo yobuthi bezinyoka ezinobuthi eningizimu ye-Anhui yenze umnikelo obalulekile ekuvimbeleni nasekulawuleni ukulimala kwezinyoka kanye nokusetshenziswa kwemithombo yobuthi benyoka e-China;Izinyoka eziyinhloko ezinobuthi eningizimu ye-Anhui i-Agkistrodon acutus (Agkistrodon acutus), i-Agkistrodon acutus, i-Cobra, i-Green Bamboo Leaf Snake, i-Chromium Iron Head kanye ne-Bungarus multicinctus, ikakhulukazi i-Agkistrodon acutus, ethinta kakhulu impilo nokuphila kwabantu abahlala ezintabeni.Ucwaningo luye lwabonisa ukuthi lezi zinyoka ezinobuthi ikakhulukazi zikhiqiza ubuthi bokujikeleza kwegazi kanye ne-neurotoxins, engabangela iziguli ukuba zihlupheke ngenxa ye-disseminated intravascular coagulation (DIC) kanye nokopha kwesibili, ukushaqeka, ukwehluleka kwezitho eziningi kanye neminye imiphumela emibi;Ngocwaningo oluhlelekile lwe-toxicology yegazi lobuthi be-Agkistrodon acutus (Agkistrodon acutus) eningizimu ye-Anhui, kwatholakala ukuthi i-DIC ehlotshaniswa nokulunywa yinyoka yayingenye yezimpawu ezingokwemvelo zobuthi bokuqala, futhi yayihlukile ku-DIC evezwa ngokwesiko. imibono.Ngakho-ke, umqondo we-“DIC like” syndrome ezigulini ezilunywe i-Agkistrodon acutus wahlongozwa okokuqala eShayina (1988), Kwabuye kwaqashelwa ukuthi i-thrombin efana ne-enzyme (TLE) kanye ne-fibrinolytic enzyme (FE) equkethwe ebuhlungwini be-Agkistrodon acutus Izimbangela eziyinhloko zalokhu "DIC like" (1992).Lokhu kubaluleke kakhulu ukucacisa izici zezinguquko zegazi ezigulini ezine-Agkistrodon acutus, futhi kuhlinzeka ngesisekelo sethiyori sokusetshenziswa kwe-antivenin ethile ukuze kwelashwe le nkinga.Ocwaningweni ngendlela yokopha okubangelwa ubuthi be-Agkistrodon acutus, kuphinde kwatholakala ukuthi lobu buthi benyoka bube nomthelela ezingxenyeni ezintathu ezinkulu zesistimu ye-hemostatic (izinto zokubopha, ama-platelet kanye nezindonga zemithambo yegazi), okuyi-haemotoxin ngqo. kuthinte ukuqina kwama-capillaries.Ngesikhathi esifanayo, kwatholakala ukuthi ukopha okungathi sína okubangelwa ubuthi be-Agkistrodon acutus venom nobunzima bokuvuvukala kwezitho ezilimele ukuze kunciphe kwakuhlobene nokuvinjelwa kwe-lymphatic supplement ye-coagulation factor ku-thoracic duct kanye nezinga elimpofu le-lymphatic flow.Lezi zimpumelelo eziyisisekelo nezisetshenziswayo eziyisisekelo zibambe iqhaza elikhulu ekubambisaneni kwesikhathi eside ne-Qimen Snakebite Research Institute ekwenzeni kahle uhlelo lokwelapha ukulunywa yinyoka enobuthi kanye nokuqinisekisa ukuphepha kweziguli ezilunywe yinyoka, futhi bathole imiphumela ebalulekile yomphakathi.Izimpumelelo zocwaningo ziwine ngokulandelanayo Indondo Yempumelelo Yesayensi Nobuchwepheshe YesiFundazwe Sase-Anhui, Umklomelo Wenqubekelaphambili Yesayensi Nobuchwepheshe WesiFundazwe Sase-Anhui (1993), kanye Nomklomelo Wezinga (A) Wokuhlangana Kwempumelelo Yesayensi Nobuchwepheshe Womnyango Wezempilo (1991);Ngo-1989, yasebenzisana ne-Wuhan Institute of Biological Products ukwakha i-monoclonal antibody ngokumelene ne-thrombin efana ne-enzyme ye-Agkistrodon acutus venom, okwakuyimpumelelo yokuqala e-China;Ngo-1996, ikhiqize ngokuhlanganyela futhi yathuthukisa imikhiqizo ye-thrombin (YWYZZ 1996 No. 118004, i-patent CN1141951A) ne-Institute of Biological Products and Drugs of Jinan Military Region.

okutholakele ocwaningweni

Eminyakeni yamuva nje, ilabhorethri ihlukanise futhi yahlanza izinhlobonhlobo zezinto eziphilayo ezivela ezinhlangeni ezingahluziwe ze-Agkistrodon acutus, i-Agkistrodon halys ne-Cobra eningizimu ye-Anhui, njengama-enzyme e-anti hypercoagulable state, ama-protein C activators (PCA).Ucwaningo lokuhlola luye lwaqinisekisa ukuthi lezi zithako ezisebenzayo zingathinta inqubo ye-coagulation, zithinte ukunamathela kwe-platelet, ukuhlanganisa nokuvikela umsebenzi wamangqamuzana e-vascular endothelial, futhi zibe nokusebenza kahle okuphezulu kanye ne-anticoagulation ephansi yobuthi kanye nemiphumela ye-thrombolytic, Lokhu kubaluleke kakhulu ekuvimbeleni nasekwelapheni. izifo ze-thrombotic kanye nokuthuthukiswa kwe-hypercoagulability yegazi;Ngesikhathi esifanayo, kuphinde kwatholakala ukuthi i-PCA evela enyokeni yenyoka inomphumela othize wokubulala amangqamuzana e-leukemia e-K562 nokuvimbela i-metastasis yamangqamuzana omdlavuza.Amathemba okusebenza kwawo emtholampilo abanzi kakhulu.Ihhovisi locwaningo lenze ngokulandelana futhi laphothula amaphrojekthi amaningi ocwaningo, njengokuthi "Indlela ye-DIC ebangelwa i-Agkistrodon acutus venom", "Ucwaningo mayelana nendlela yokopha okubangelwa i-Agkistrodon acutus venom ezilwaneni", "Ukuxilongwa kokulunywa yinyoka kanye nokuxilongwa okuhlukile kobuhlungu bayo. umndeni wezinyoka ngendlela yokulebula nge-enzyme”, exhaswe yiNational Natural Science Foundation, uMnyango Wezempilo, uMnyango Wezempilo kanye noMnyango Wezemfundo WesiFundazwe sase-Anhui;Njengamanje, amaphrojekthi asathuthukiswayo ahlanganisa: "Ucwaningo Lwephrotheni Ye-Hemorrhagic Anticoagulant ye-Agkistrodon acutus", "Ucwaningo Lwendlela Yemolekyuli Yomphumela we-PCA evela ku-Agkistrodon halys Pallas Venom ku-Vascular Endothelial Function", "Ucwaningo Lwebhayoloji Ye-Molecular I-PCA evela ku-Agkistrodon acutus Venom ngokumelene namaseli E-Tumor”, kanye Nokwehlukaniswa Nokuhlanzwa Kwezingxenye Ze-Nerve Analgesic from Cobra Venom.

Isikhungo sokucwaninga ngobuthi benyoka saseSouth Anhui Medical College sinezimo ezinhle eziyisisekelo, imishini yokucwaninga ephelele, ukwakheka kweqembu labacwaningi okunengqondo, kanye nenqubekelaphambili eqhubekayo ezindleleni zocwaningo nezindlela zobuchwepheshe.Kulindeleke ukuthi kube nezimpumelelo ezintsha ocwaningweni lwesayensi, ukuqeqeshwa kwabasebenzi, njll. Izinsiza ze-snake poison eningizimu ye-Anhui zicebile kakhulu futhi ziyigugu.Ikhemisi lobuthi bezinyoka umuthi onamalungelo empahla yengqondo e-China.Imiphumela yocwaningo ngesisekelo kanye nokusetshenziswa kobuthi benyoka kanye nezingxenye zayo ibaluleke kakhulu ekuthuthukisweni kwezinsiza ezinothile zesihlungu senyoka eningizimu ye-Anhui kanye nokusetshenziswa komtholampilo.