Ukuhlukaniswa kwezingxenye ze-anticoagulant kanye ne-fibrinolytic kusuka ku-Agkistrodon acutus venom kanye nemiphumela yazo ohlelweni lokuhlangana.
Injongo: Ukufunda umphumela we-thrombin ehlanzekile njenge-enzyme ne-plasmin evela ku-Agkistrodon acutus venom ohlelweni lokuhlangana kwegazi
Izindlela: I-Thrombin efana ne-enzyme kanye ne-plasmin yahlukaniswa futhi yahlanzwa ebuhlungwini be-Agkistrodon acutus nge-DEAE Sepharose CL-6B kanye ne-Sephadex G-75 chromatography, futhi imiphumela yazo kuzinkomba zesistimu yokuhlangana yabonwa ngokuhlolwa kwe-vivo.Imiphumela: I-Thrombin efana ne-enzyme kanye ne-plasmin kwahlukaniswa ubuthi be-Agkistrodon acutus, futhi izisindo zazo zamangqamuzana ezihambisanayo zazingu-39300 no-26600, ngokulandelana, Womabili ama-thrombin afana ne-enzyme kanye ne-plasmin evela ku-Agkistrodon acutus venom angakwazi ukwandisa ngokuphawulekayo sonke isikhathi sokuhlangana kwegazi, okwenziwa kusebenze ingxenye. isikhathi, isikhathi se-thrombin nesikhathi se-prothrombin, nokunciphisa okuqukethwe kwe-fibrinogen, kodwa umphumela we-thrombin njenge-enzyme unamandla, kuyilapho i-plasmin ibonisa umphumela we-anticoagulant kuphela ngethamo elikhulu, futhi inhlanganisela yakho kokubili ingcono kunokusebenzisa kwabo okukodwa.
Isiphetho:
I-Thrombin efana ne-enzyme kanye ne-plasmin evela ku-Agkistrodon acutus venom inomthelela ohlelweni lokuhlangana kwegazi ezilwaneni, futhi inhlanganisela yakho kokubili inomphumela osobala we-anticoagulant.
Isikhathi sokuthumela: May-10-2023