Ubuhlungu benyoka bunezingxenye eziningi ze-bioactive, ikakhulukazi ezihlanganisa i-protease ne-polypeptide
Ibalelwa ku-90% ~95% wesisindo esomile sobuthi benyoka [l
Ngokuthuthuka okuqhubekayo kobuchwepheshe, izithako eziningi ze-biological ezisebenzayo ebuhlungwini benyoka kancane kancane
Iye yahlukaniswa futhi yahlanzwa, futhi abantu baye benza kanjalo
Yenza ucwaningo olunzulu ngayo ngenhloso yokusebenzisa izithako zokwelapha ezinobuthi benyoka kubantu
Ekwelapheni izifo ezifanayo.Njengamanje, izithako ezisebenzayo zezidakamizwa ezisebenzayo eziqukethwe ebuhlungwini benyoka
Ucwaningo lwezidakamizwa kanye nokusetshenziswa komtholampilo okwenziwe kugxile kakhulu ku-antithrombotic, hemostatic kanye ne-hypoglycemic
Ingcindezi, anti-umdlavuza namaphilisi ezinhlungu.
L Izidakamizwa ze-Antithrombotic
I-snake venom protease ene-anti-thrombotic kanye ne-thrombolytic effect ikakhulukazi ihlanganisa i-Ancelor
I-Enzyme (i-hoe crod), i-batmxobin, i-defibrase (de coerase) ne-Agkistrodon acutus
I-enzyme (autobin).Amathathu okuqala angawe-snaI [e venom
I-Thmmbin njengama-enzynles, s Ⅷ.E), i-sVTLE iyi-serine protease, efanayo ne
Ine-arginine esterase kanye nomsebenzi we-amidase - 1. I-enzyme efana ne-snake venom thrombin-like
Isebenza ku-fibrinogen ukukhulula i-fibrinogen A noma B, ngaleyo ndlela
Ingakwazi ukuhlanganisa i-polymerization yekhanda nomsila we-fibrin monomer, ngoba ibonisa i-thrombin.
Isebenza futhi ibizwa nge-thrombin-like.Ngesikhathi esifanayo, i-enzyme efana ne-thrombin enobuhlungu benyoka ayikwazi ukutholakala kubantu
Yenza kusebenze i-coagulation factor x Ⅲ ku-vivo, futhi i-fibrin monomer ekhiqizwa i-hydrolysis yayo
I-polymerization yekhanda nomsila, kodwa ayikwazi ukukhiqiza i-side chain cross-linking, okulula ukulinyazwa uhlelo lwemvelo lwe-reticuloendothelial
Izinga le-plasma fibrinogen liyancipha ngenxa ye-phagocytosis noma ukuwohloka kwesistimu ye-fibrinolytic
Isesimweni se-benign fibrinolytic, ngakho-ke ikhombisa i-anticoagulation nokucindezeleka emzimbeni
I-Fibrillation H1.I-Agkistrodon acutus enzyme iyingxenye ye-fibrinolytic enzyme, okuyi-fibrinolytic
Isifinyezo se-enzyme [Erin (ogen) ol "icenzyme, FLE] singahlukaniswa sibe iketango elilodwa
I-Zinc metalloproteinase kanye ne-single-chain noma i-double-chain serine protease, ikakhulukazi iqanda lensimbi ye-zinc
I-enzyme emhlophe.I-enzyme ye-snake venom fibrinolytic ayidingi ukusebenza kwe-activator, futhi ingasika ngokuqondile imicu.
Iphrotheni (protogen) ikhiqiza i-hemofibrin, ngakho ngeke ibangele ukuhlangana “J.
Kusukela ebuhlungwini be-Agkistrodon halys (isb. sek, № r [md ∞ to, ship) e-Malaysia
I-ankylose ehlukanisiwe yaba ngeyokuqala ukusetshenziswa ekwelapheni izifo ze-thrombotic
Isidakamizwa se-SVTLE.6 J. Ngemva kokuthuthuka kwe-Ancelose, yake yafundwa amazwe amaningi
Abacwaningi bakholelwa ukuthi i-sV'11E iwumuthi othembisayo kakhulu wokwelapha izifo ze-thrombotic,
Ngaphezu kokusetshenziselwa ukwelapha i-peripheral thrombosis, ingasetshenziswa futhi ekwelapheni i-thrombosis ejulile ye-venous kanye ne-central thrombosis.
I-Pulse thrombosis nayo inomphumela wokwelapha “J.Ngawo-1990, amazwe amaningi nezifunda
U-Qu Du unentshisekelo enkulu ekwelapheni i-acute cerebral ischemia kanye ne-stroke nge-aclase, futhi
Iphrojekthi yesikhwama: Iphrojekthi Yentsha Yesayensi Yezokwelapha Nobuchwepheshe Yokuthuthukisa Intsha (13QNP068);Ibutho lonke “12
5 “iphrojekthi yocwaningo lwezokwelapha jikelele (cwslJ280);Isifunda Sezempi sase-Chengdu "Uhlelo Lweminyaka Emihlanu Yeminyaka Emihlanu" Ucwaningo Lwezokwelapha
Amaphrojekthi abalulekile (B12026);Iphrojekthi yocwaningo lwezokwelapha olujwayelekile lweSifunda Sezempi sase-Chengdu phakathi noHlelo Lweminyaka Eyi-12 Lweminyaka Emihlanu
(C12062)
Iyunithi yombhali: 650032 Kunming, Chengdu Military Region Centre for Disease Control and Prevention (Zhang Zhixiao,
Hu Tingsong, Cui Qinghua, Zheng Ying, Fan Quanshui);Amagciwane, Isikole Semithi Eyisisekelo, i-Youjiang Medical College yezizwe
Ihhovisi Lokufundisa Nokucwaninga Ngebhayoloji ne-Immunology (Xie Zhenfeng)
Umbhali ohambelanayo: Fan Quanshui, I-imeyili: fqsl68@126.com
Kuye kwenziwa izifundo eziningana zezicelo zomtholampilo ezincane.Inkomba yokuhlola ukusetshenziswa kwezidakamizwa kokuqala
Ngaphezu kwalokho, i-Ancelose ingasetshenziswa ekwelashweni komtholampilo kweziguli ezine-acute ischemic stroke esigabeni sokuqala
Ibonisa umphumela omuhle wokwelapha.Ngemva kwalokho, ngesilinganiso esikhulu esingahleliwe esingaboni kahle kabili, ipheya ye-placebo
Ngokusho kocwaningo lomtholampilo, yena, njll. Ezimweni ezingu-2613 ze-acute
Imiphumela yokwelashwa kwezidakamizwa yeziguli ezine-ischemic stroke yocansi iqinisekisile ukuthi iziguli eziseqenjini le-cloroxobin
Izinga lokusinda liye landa kakhulu, kodwa ingozi yokopha nge-intracranial nayo yanda.Ngemva kwalokho
Ukuhlolwa komtholampilo kweziguli eziyi-1222 ezine-acute ischemic stroke sikuqinisekisile lokho ngemuva kwamahora ama-3
I-Ancelose ayinconywa ukwelashwa.1…. I-United States neCanada yashicilelwa ngo-2009
Imivimbo engu-500 ehilela amazwe angu-12 nezifunda ezihlanganisa i-Canada ne-Australia
ngiguliswa
Isikhathi sokuthumela: Feb-26-2023