Ukutadisha umphumela wama-enzyme afana ne-thrombin kanye ne-fibrinolytic ahlukanisiwe futhi ahlanzwa ku-Agkistrodon acutus venom efanayo ohlelweni lokuhlangana kwegazi.Izindlela: Ama-enzyme afana ne-thrombin ne-fibrinolytic ahlukaniswa futhi ahlanzwa ku-Agkistrodon acutus venom nge-DEAE-Sepharose CL-6B kanye ne-Sephadex G-75 chromatography, futhi umthelela walokhu okubili kuzinkomba zesistimu yokuhlangana kwegazi wabonwa ngokuhlolwa kwe-vivo.Imiphumela: Ingxenye eyodwa yama-enzyme afana ne-thrombin-like kanye ne-fibrinolytic ahlukanisiwe ku-Agkistrodon acutus venom, ngokulandelana, Isisindo sawo samangqamuzana angama-39300 no-26600, ngokulandelana.Ukuhlolwa kwe-vivo kufakazele ukuthi womabili ama-enzyme afana ne-thrombin-like kanye ne-fibrinolytic avela ku-Agkistrodon acutus venom angandisa kakhulu isikhathi sokuhlangana kwegazi, isikhathi se-prothrombin esicushiwe, isikhathi se-thrombin nesikhathi se-prothrombin, futhi anciphise okuqukethwe kwe-fibrinogen, kodwa indima ye-thrombin- njengama-enzyme anamandla, kuyilapho ama-enzyme e-fibrinolytic abonisa umphumela we-anticoagulant ngemithamo emikhulu kuphela, Isiphetho: I-enzyme efana ne-Thrombin ne-fibrinolytic enzyme evela ku-Agkistrodon acutus venom kunemiphumela ohlelweni lokuhlangana kwegazi ezilwaneni, futhi inhlanganisela yakho kokubili inomphumela osobala we-anticoagulant.
Isikhathi sokuthumela: Jan-10-2023