[Abstract] Injongo Ukuphenya umthelela ovimbelayo wengxenyana encane ye-polypeptide yamangqamuzana (K) kusuka ku-Agkistrodon acutus venom ekwandeni komugqa weseli lomdlavuza wesibeletho somuntu A2780 kanye nendlela yawo.Izindlela zokuhlolwa kwe-MTT zasetshenziswa ukuthola ukuvimbela ukukhula kwengxenye ye-K emigqeni yamaseli omdlavuza;I-anti-cell adhesion effect ye-K ingxenye yabonwa ukuhlolwa kokunamathela;I-AO-EB double fluorescence staining kanye ne-flow cytometry yasetshenziswa ukuthola ukwenzeka kwe-apoptosis.Ingxenye yemiphumela ye-K ivimbele ukwanda komugqa weseli yomdlavuza wesibeletho somuntu A2780 ebudlelwaneni besikhathi-nomphumela nomthamo, futhi ingamelana nokunamathela kwamaseli ku-FN.I-Apoptosis itholwe yi-AO-EB double fluorescence staining kanye ne-flow cytometry.Isiphetho Ingxenye K inomphumela obalulekile wokuvimbela ekwandeni komugqa wamangqamuzana omdlavuza we-ovarian womuntu A2780 in vitro, futhi indlela yawo ingase ihlobane nokunamathela kokulwa namaseli kanye nokungeniswa kwe-apoptosis.
Isikhathi sokuthumela: Jan-11-2023