Ubuthi Benyoka obuvela ku-Agkistrodon (Inyoka enezinyathelo ezinhlanu) Kufanele Yelashwe Ngesithombe Esifakiwe Se-Antihematic Serum

Ubuthi Benyoka obuvela ku-Agkistrodon (Inyoka enezinyathelo ezinhlanu) Kufanele Yelashwe Nge-Antihematic Serum

Incazelo emfushane:

Izivivinyo ezimbili zomtholampilo zenziwa, isilingo esilawulwa yi-placebo esingahleliwe kanye nesilingo esilawulwa kahle esilawulwa ngokungahleliwe.Wonke amanxeba ayephuma igazi ngenxa yokusikwa odongeni lwesisu lapho ehlinzwa esiswini.Izinkomba eziyinhloko zokwelapha kwakuwukulahlekelwa igazi, isikhathi se-hemostasis nokulahlekelwa kwegazi endaweni yeyunithi ngayinye.I-placebo engahleliwe ezivivinyweni zomtholampilo ezimweni eziyi-180 zabantu: ingxenye yamaphuzu alinganayo angahleliwe ku-placebo, ama-2 u no-3 u amaqembu amathathu, i-preoperative imizuzu eyi-15-20 umthamo owodwa womjovo, imiphumela iphakamisa lokhu imithamo emibili ukopha, isikhathi sokopha kanye ukulahleka kwegazi ngeyunithi ngayinye yenkomba bekuphakeme kune-placebo, kodwa abukho ubudlelwano bokugxila nokusabela phakathi kwamaqembu amabili.Esivivinyweni sokulawula esihle, kwakukhona iziguli ezingu-324 eqenjini lokuhlola kanye neziguli ezingu-108 eqenjini lokulawula, futhi umthamo owodwa we-2U wanikezwa eqenjini lokuhlola imizuzu engu-15-20 ngaphambi kokuhlinzwa ngomjovo owodwa womthanjeni.Akukho ukusabela okubi okubonwe kulezi zivivinyo ezingenhla.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ucwaningo selukhombisile ukuthi lezi zinyoka ezinobuthi ikakhulukazi zikhiqiza ubuthi obujikeleza igazi kanye nama-neurotoxins, angabangela i-diffuse intravascular coagulation (DIC) nokopha okulandelayo, ukushaqeka kanye nokwehluleka kwezitho eziningi.Ngokusekelwe ocwaningweni oluhlelekile lwe-blood toxicology yobuthi benyoka eningizimu ye-Anhui, i-DIC itholwe ingenye yezimpawu zemvelo zeziguli ezilinyazwe yinyoka ezinoshevu wangaphambi kwesikhathi, owawuhlukile ekukhulumeni kwendabuko kwe-DIC.Ngakho-ke, umqondo we-"DIC like" syndrome ezigulini ezilunywe yinyoka wahlongozwa okokuqala eChina (1988).Kwatholakala ukuthi i-TLE kanye ne-FE yizona zimbangela eziyinhloko zalokhu "i-DIC efana" (1992).Lokhu kubaluleke kakhulu ukucacisa izici zezinguquko zegazi ezigulini ezinobuthi benyoka obuyizinyathelo ezinhlanu, futhi kunikeza isisekelo sethiyori sokusetshenziswa kwe-antivenin ethize ukwelapha le nkinga.

Ocwaningweni ngendlela yokopha okubangelwa ubuthi benyoka obuyizinyathelo ezinhlanu, kuphinde kwatholakala ukuthi lobu buthi benyoka bunomphumela ezingxenyeni ezintathu zesistimu ye-hemostatic yomzimba (izici zokuhlangana, ama-platelet kanye nodonga lwemithambo yegazi), phakathi kwawo ukopha. ubuthi buthinta ngqo ukungena kwama-capillaries.Ngesikhathi esifanayo, kwatholakala ukuthi ukopha okukhulu nokuvuvukala kwezitho ezilimele kwakungelula ukuxazulula, okwakuhlobene nokuvinjelwa kokunikezwa kwegazi kwe-thoracic duct lymphatic coagulation factor kanye nesivinini esibi sokugeleza kwe-lymphatic.Ekubambisaneni kwesikhathi eside ne-qimen Snakebite Institute, le miphumela yocwaningo eyisisekelo nesetshenziswayo ibambe iqhaza elibalulekile ekwakhekeni ngempumelelo uhlelo lokwelapha ukulunywa yinyoka kanye nokuqinisekisa ukuphepha kweziguli ezilunywe yinyoka, futhi izuze imiphumela ebalulekile yomphakathi.Impumelelo yocwaningo iwine Umklomelo Wempumelelo Yesayensi Nobuchwepheshe YesiFundazwe Sase-Anhui, Umklomelo Wenqubekelaphambili Yesayensi Nobuchwepheshe Esifundazweni Sase-Anhui (1993), Umnyango Wezempilo (A) Umklomelo Weqembu Lempumelelo Yeqembu Lesayensi Nobuchwepheshe (1991);Ngo-1989, inkampani yabambisana ne-Wuhan Institute of Biological Products ukuthuthukisa i-monoclonal antibody ngokumelene ne-penta snake venom thrombin, okwakuyimpumelelo yokuqala e-China.Ngo-1996, inkampani yakhiqiza ngokuhlanganyela futhi yathuthukisa imikhiqizo ye-thrombin ne-Institute of Biological Products and Drugs of Jinan Military Command (Yuwei Drug Approval No. 118004, Patent CN1141951A).