Kusetshenziswe Imiphumela Eyisikhombisa Ye-Antithrombotic Isithombe Esifakiwe

Kwasetshenziswa Imithelela Eyisikhombisa Ye-Antithrombotic

Incazelo emfushane:

Kunezinhlobo ezimbili zamaphrotheni ebuhlungwini benyoka, eyodwa yazo iqondile.I-enzyme encibilikisa i-fibrin (protolysin) ibizwa ngokuthi i-fibrin (protolysin) i-enzyme (Ifushane nge-plasminase,fi b ri no L yt I cenz YM E, FLE).Ngaphezu kokululaza i-fibrin ne-fibrinogen, Akukho ukusebenza kwe-plasminogen emzimbeni womuntu, akukho hydrolysis kwezinye izici coagulation Futhi ulwelwesi lweplatelet, inomphumela osobala we-antithrombotic.Enye ingokucindezela iProthrombin icushiwe ukuze ibambezele inqubo yokuhlangana futhi ayinawo umsebenzi we-enzyme.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Le enzyme yaqala ukukhiqizwa yi-ATODA njll. kusuka ebuhlungwini benyoka yekhanda lensimbi yaseJapan ephuzi-luhlaza
Kwaxoxwa nge-anticoagulant mechanism ye-anticoagulant protein.
Lokhu kuboniswa ngokusebenzisana ne-clotting factor IX noma i-clotting factor X kuma-ion e-calcium
Ukwakheka kwe-1: 1 inkimbinkimbi ukuze kuzuzwe isikhathi eside sokuhlangana;Kamuva,
LU et al.Agk I strodona CU
I-ACFI, i-anticoagulant factor, yahlukaniswa nobuhlungu benyoka.U-Liu Qing
Liang et al.wafunda i-anticoagulant factor futhi wathola ukuthi i-AC FI iqukethe i-calcium ion
Futhi umsebenzi wayo we-anticoagulant kanye nesakhiwo sendawo kwakuhlotshaniswa ne-calcium ions.
Ngokulandelayo, uXu Xiaolong et al.ihlukanise ubuthi be-agkistrodon halys ngendlela yokuhlukanisa ethuthukisiwe
Esinye isici se-anticoagulant, i-ACFI I, kanye ne-anticoagulant yalesi sici se-anticoagulant.
Ucwaningo lokusetshenziswa kwemishini, lwathola ukuthi olufana ne-AC FI, luwuhlobo lwesibili.zhayi
Ning et al.ihlukanise isici esisha se-anticoagulant ebuhlungwini be-agkistrodon agkistrodon
Kwatholakala ukuthi wawungekho umsebenzi we-fibrinolytic kanye ne-phospholipase A
Umsebenzi nokopha umsebenzi.U-Qian Xiaojiang et al wase-Hunan bakhiqize amaphuzu e-agkistrodon poison
Izingxenye ezisebenzayo ze-Fibrinolytic zahlukaniswa futhi zaqinisekiswa i-thrombolytic assay in vitro
Inomphumela osobala we-thrombolytic.Ukuhlanzeka kwahlukaniswa ngezindlela ezintathu ze-chromatographic
Futhi umsebenzi wama-enzyme wathuthukiswa kakhulu.Ngoba ingxenye ye-plasminase iqukethe
Ingxenye yokopha kunzima ukuhlukaniswa futhi ukubaluleka kwayo komtholampilo akubonakali.Li Zhaoyan njll.
Ngemizamo yokuthola i-enzyme ye-fibrinolytic ngaphandle kwezingxenye zokopha, impendulo yomtholampilo ye-fibrinolytic enzyme
Ngokusekelwa kobuchwepheshe.UZhou Xianli [18] wafakazela ngokuhlolwa ukuthi
Kokubili i-thrombin ne-fibrinolytic enzyme ye-agkistrodon halys venom inomphumela osobala we-thrombolytic, kodwa
Umphumela oqondile we-fibrinolytic enzyme unamandla kune-thrombin.
Ngakho-ke i-thrombin i-thrombolytic kancane, ukuvuselelwa okuqhubekayo kwemithambo yegazi,
Thuthukisa ukubekezelelana kwemithambo yegazi endaweni ye-ischemic, gwema ukugcwala kwegazi okubangelwa ukuphuka kwemithambo.
I-Cleft, inomphumela ongcono esigabeni sokuqala se-thrombosis, ukusetshenziswa okubili okuhlangene